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Technologies for Metabolic Monitoring
Julia Weaver Fund
FY01 TMM Research Projects
FY02 TMM Research Projects
FY03 TMM Research Projects
Solicitations
Research News
Opportunities for Research Support
Contacts

FY04 SOLICITATION ANNOUNCED!!!

The Technologies for Metabolic Monitoring (TMM) and Julia Weaver Fund (JWF) Research Program is a collaborative initiative between the U.S. Army Medical Research and Materiel Command (USAMRMC), the Juvenile Diabetes Research Foundation (JDRF), National Aeronautical and Space Administration (NASA), and the National Institutes of Health (NIH, NIDDK). It was initiated and is directly sponsored by Congress and has been chiefly supported by the Honorable George Nethercutt (R-WA).

In FY03, Congress increased the budget resources for TMM based on the testimony before the Senate Appropriations Committee on Defense of Major General Paul A. Weaver, Jr., retired director of the U.S. Air National Guard and the father of an almost 3-year old daughter with juvenile diabetes. To remember this pivotal occasion, the research program has been renamed in 2003 to the Technologies for Metabolic Monitoring (TMM) and Julia Weaver Fund (JWF) Research Program. Additional support from Senators Susan Collins (R-ME), Mark Dayton (D-MN), and Daniel K. Inouye (D-HI), Chairman of the Subcommittee on Defense for the Senate Appropriations Committee, helped secure the funds in the Senate.

The TMM and JWF Research Program was initiated to identify and expand research areas that have a direct impact on the capability to monitor, understand, and predict metabolism under a wide array of circumstances. This program’s focus is to provide support and assistance in the identification and maturation of potential new, novel, and innovative technologies and techniques for the monitoring and assessment of metabolism, especially those that may apply to the care and long-term health maintenance of diabetic patients. The overall program goal of the TMM and JWF Research Program is to fund scientifically meritorious research in accordance with directives received from Congress. The DoD, JDRF, NASA, and NIH have formed an advisory group for the TMM and JWF Research Program.

The initiative will develop a means to understand, predict and closely monitor metabolic products, with an emphasis on monitoring blood glucose levels. The development of TMM would also have a significant application in protecting the men and women of the armed forces, including the potential for additional metabolic monitoring in the field to determine health status and accurately communicate this information. Furthermore, it would provide technology enabling the delivery of drug treatments and nutritional supplements to protect and enhance performance in military personnel.

FY01 TMM Research Projects    ^BACK TO TOP^

Non-Invasive and Non-Intrusive Method of Measuring Internal Metabolic Processes, as well as Monitoring of Stress Hormones
Principal Investigator, Kaveh Zamani

Integration and Optimization of Advanced, Non-invasive, Ambulatory Monitoring Technologies for Operational Metabolic Monitoring
Principal Investigator, Jerome Shultz

Measurement of IGF-1 During Military Operational Stress via a Filter Paper Spot Assay
Principal Investigator, Bradley Nindl

The Warfighter’s Stress Response: Telemetric and Non-invasive Assessment
Principal Investigator, Amanda O’Donnell

Interstitial Metabolic Monitoring During Hemorrhagic Shock
Principal Investigator, Motilal Pamanani

FY02 TMM Research Projects    ^BACK TO TOP^

Metabolic Rate Monitoring and Energy Expenditure Prediction Using a Novel Actigraphy Method
Principal Investigator, Daniel S. Moran

Portable Physical Activity Monitors for Measuring Energy Metabolism in ROTC Cadets
Principal Investigator, Kong Y. Chen

Skin Bioengineering: Non-invasive, Transdermal Monitoring
Principal Investigator, Richard H. Guy

Fluorescent Polymer Implant for Continuous Glucose Monitoring and Feedback (proposal)
Principal Investigator, Ralph Ballerstadt

Towards Miniaturized, Wireless-Integrated, and Implantable Glucose Sensors
Principal Investigator, Diane J. Burgess

Implantable Multi-Sensor Array for Metabolic Monitoring
Principal Investigator, David A. Gough

Improved Metabolic Monitoring and Hyperspectral Methods for Wound Characterization (proposal)
Principal Investigator, Stuart Harshbarger

Evaluation and Refinement of a System and a Method for the Use of Hyperspectral Imaging for Metabolic Monitoring
Principal Investigator, James Mansfield

Non-Invasive Monitoring of Insulin-like Growth Factor-I During Differential Physical Training Programs in Warfighters
Principal Investigator, Bradley Nindl

A Minimally-Invasive Dual-Analyte Miniaturized Continuous Sensor for Glucose and Lactate
Principal Investigator, W. Kenneth Ward

A Hydrogel-Based, Implantable, Micromachined Transponder for Wireless Glucose Measurement
Principal Investigator, Babak Ziaie

FY03 TMM Research Projects    ^BACK TO TOP^

Implementation of the Implantable Multi-Sensor Metabolic Monitor
Principal Investigator, David Gough

Novel Micro/Nano Approaches for Glucose Measurement Using pH-Sensitive Hydrogels
Principal Investigator, Michael McShane

Uses of Neovascularization to Enhance Glucose Sensor Function In Vivo
Principal Investigator, Donald Kreutzer

Artificial Pancreas for Control of BG and Insulin Levels in Hospitalized Patients with Diabetes and Stress Hyperglycemia
Principal Investigator, Jeffrey Joseph

Indwelling Metabolite Sensors for Optical Reading Through Skin: A Platform Based on NIR Dyes Conjugated to Binding Proteins
Principal Investigator, Joseph Thomas

Non-Invasive Metabolic Monitoring Using a Breath-by-Breath Microfluidic Gas
Principal Investigator, Tadeusz Drzewiecki

Glucose-Responsive Nanoparticles for Controlled Insulin Delivery
Principal Investigator, Jackie Ying

Role of Macrophages in the Function and Lifespan of Glucose Sensors In Vivo
Principal Investigator, Donald Kreutzer

Solicitations    ^BACK TO TOP^
FY02

Research Program in Technologies for Metabolic Monitoring (TMM)
http://www.usamraa.army.mil/pages/index.cfm

FY03

Research Program in Technologies for Metabolic Monitoring (TMM) and Julia Weaver Fund (JWF) Broad Agency Announcement (BAA)
http://www.usamraa.army.mil/pages/index.cfm

FY04

FY04 SOLICITATION ANNOUNCED!!!

Research Program in Technologies for Metabolic Monitoring (TMM) and Julia Weaver Fund (JWF) Broad Agency Announcement (BAA) MRMC-BAA-TMM04
http://www.usamraa.army.mil/pages/index.cfm
Deadline for receipt of BAA proposals: 31 December 2003

Department of Defense SBIR Solicitation (PDF)
DoD begins accepting SBIR proposals: 1 December 2003
Deadline for receipt of SBIR proposals: 15 January 2004

OSD04-DH2 Non-Invasive Metabolic Monitoring
http://www.acq.osd.mil/sadbu/sbir/solicitations/sbir041/index.htm (Use table, "OSD Topics")

Research News    ^BACK TO TOP^

Current announcements on solicitations, meetings/conferences, and short articles

Third Annual Diabetes Technology Meeting a Success!

Held in San Francisco, California, November 6-8, this third annual meeting provided an excellent opportunity for clinicians, engineers and leading scientists to meet and learn about the latest technological advances and their applications in the fight against diabetes - artificial pancreas, metabolic monitoring, case management, telemedicine, metabolic modeling, educational tools, software, and hardware. Attendees had opportunities to share ideas and gain insight into helping decrease the physical and psychological burden of diabetes. They were given a live demonstration of continuous glucose monitoring technologies from Germany. LTC Carl Hover, MOMRP Deputy Director, and Dr. Kim Hunter-Schaedle, Juvenile Diabetes Research Foundation, co-chaired the Technologies for Metabolic Monitoring session that opened the meeting. COL Karl Friedl, Commander, U.S. Army Research Institute of Environmental Medicine chaired a Forum on Lactate Measurements for Metabolic Monitoring.

In recognition of their significant leadership, vision, and research, Dr. David Klonoff, Chairman of the Diabetes Technology Society presented COL Karl Friedl, PhD, and LTC Carl Hover, PhD, with The Diabetes Technology Leadership Award – 2003. This award acknowledges the recipients application of science and engineering to fight diabetes.

The Fourth Annual Diabetes Technology Meeting will be held 28-30 October 2004 in Philadelphia, Pennsylvania. Watch this site or http://www.diabetestechnology.org for further details.

Diabetes Technology & Therapeutics journal bimonthly subscription: http://www.liebertpub.com/dia

Opportunities for Research Support    ^BACK TO TOP^

Further information about other programs and funding opportunities related to research in metabolic monitoring, please use the following links.

Contacts    ^BACK TO TOP^

For more information about applications for funding for the USAMRMC Research Programs, including TMM, please go to http://www.usamraa.army.mil/pages/index.cfm, http://mrmc-www.army.mil/, and/or http://www.acq.osd.mil/sadbu/sbir/.

If you have any questions or would like more information on the TMM Research Program, please direct your inquiries to TMMRProgram@anteon.com.

Last Update: February 23, 2004