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Inhalation Injury and Toxicology Models

Army Science and Technology Objective: IV.ME.2000.06

Inhalation Injury and Toxicology Models

Problem

Combat operations, such as those in smoke-filled buildings or in armored vehicles penetrated by armor-piercing rounds, can expose soldiers to complex toxic gas mixtures. These exposures, even short-term, can cause performance degradation, incapacitation, or death. The Army lacks biomedically valid methods for assessing weapon systems and operational scenarios for the potential to produce inhalation injury.

Medical Research Solution

Develop advanced physiological models and use toxic gas exposure studies with small animals to incrementally develop Toxic Gas Assessment Software (TGAS) for survivability assessments and operational simulations.

Products

  • TGAS v.1 - predicts probability of immediate incapacitation from combined gas exposures (CO, HCN, NO2, HCL, and Acrolein).
  • TGAS v.2 - adds effects of combined gas exposures on breathing rate.
  • TGAS v.3 - adds effects of exposures to irritant gases, halon replacement gases, and predicts delayed lung injury and performance decrements.
  • TGAS v.4 - adds effects of physical exertion and particles and aerosols.
  • TGAS v.5 - adds effects of heat, cold, and altitude, and transitions to end users.

Last Update: April 2, 2003